Short answer: Yes.

As Jane M. Von Bergen rightly points out, if the phrase "at the end of the day" was used sparingly and effectively then we would welcome its use today as a preface to deeply significant observations; instead, because the phrase has become so hackneyed, it is rendered meaningless.

What makes at the end of the day so particularly revolting is the phrase's truth-in-advertising problem.

I get excited when people sound as if they are about to emit wisdom. That end of the day phrase tunes me up in anticipation of a Tuesdays With Morrie-level insight, something meaningful, something important.

Enough is Enough [Philadelphia Inquirer via Obscure Store]